Glasgow is the largest city in Scotland and third most populous in the United Kingdom. The city is situated on the River Clyde in the country's west central lowlands. A person from Glasgow is known as a Glaswegian. Glasgow grew from the medieval Bishopric of Glasgow and the later establishment of the University of Glasgow in the 15th century, which subsequently became a major centre of the Scottish Enlightenment in the 18th century. From the 18th century the city also grew as one of Britain's main hubs of transatlantic trade with British North America and the British West Indies.